Reaction Details Report a problem with these data
Target
Thromboxane A2 receptor
Ligand
BDBM50171470
Substrate
n/a
Meas. Tech.
ChEMBL_303672 (CHEMBL830433)
Ki
>5900±n/a nM
Citation
 Ohno, M; Miyamoto, M; Hoshi, K; Takeda, T; Yamada, N; Ohtake, A Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives. J Med Chem 48:5279-94 (2005) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane alpha
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Human
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50171470
Synonyms:
CHEMBL191162 | {3-[2-(1,1-Diphenyl-butylsulfanyl)-ethyl]-2-hydroxymethyl-benzofuran-7-yloxy}-acetic acid
Type:
Small organic molecule
Emp. Form.:
C29H30O5S
Mol. Mass.:
490.611
SMILES:
CCCC(SCCc1c(CO)oc2c(OCC(O)=O)cccc12)(c1ccccc1)c1ccccc1
Structure:
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