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Target
Sodium/glucose cotransporter 2
Ligand
BDBM50559516
Substrate
n/a
Meas. Tech.
ChEMBL_2267441
Ki
12±n/a nM
Citation
 Flick, AC; Leverett, CA; Ding, HX; McInturff, E; Fink, SJ; Mahapatra, S; Carney, DW; Lindsey, EA; DeForest, JC; France, SP; Berritt, S; Bigi-Botterill, SV; Gibson, TS; Liu, Y; O'Donnell, CJ Synthetic Approaches to the New Drugs Approved during 2019. J Med Chem 64:3604-3657 (2021) [PubMed] 
Target
Name:
Sodium/glucose cotransporter 2
Synonyms:
Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:
Protein
Mol. Mass.:
72902.00
Organism:
Human
Description:
P31639
Residue:
672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQAPAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLMMAVAVFLWGFYA
  
Inhibitor
Name:
BDBM50559516
Synonyms:
GSK-189075 | GSK-189075A | GSK189075A | Remogliflozin etabonate
Type:
Small organic molecule
Emp. Form.:
C26H38N2O9
Mol. Mass.:
522.5879
SMILES:
[H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r|
Structure:
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