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Target
Type-1 angiotensin II receptor
Ligand
BDBM50209827
Substrate
n/a
Meas. Tech.
ChEMBL_455320 (CHEMBL886096)
IC50
16±n/a nM
Citation
 Xu, JY; Zeng, Y; Ran, Q; Wei, Z; Bi, Y; He, QH; Wang, QJ; Hu, S; Zhang, J; Tang, MY; Hua, WY; Wu, XM Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists. Bioorg Med Chem Lett 17:2921-6 (2007) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_BOVIN | Angiotensin II type 1a (AT-1a) receptor
Type:
PROTEIN
Mol. Mass.:
41107.81
Organism:
Bos taurus
Description:
ChEMBL_36779
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFIMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPTIIHRNVFFIENTNITVCAFHYESQNSTLPVGLGLTKNILGFLFPFLIILTSYTLIWKTLKKAYEIQKNKPRKDDIFKIILAIVLFFFFSWVPHQIFTFMDVLIQLGLIRDCKIEDIVDTAMPITICLAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSENGNSSTKKPAPCIEVE
  
Inhibitor
Name:
BDBM50209827
Synonyms:
3-(4-(2-(1H-tetrazol-5-yl)-1H-pyrrol-1-yl)benzyl)-2-propyl-3H-benzo[d]imidazole-4-carboxylic acid | CHEMBL241523
Type:
Small organic molecule
Emp. Form.:
C23H21N7O2
Mol. Mass.:
427.4585
SMILES:
CCCc1nc2cccc(C(O)=O)c2n1Cc1ccc(cc1)-n1cccc1-c1nnn[nH]1
Structure:
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