Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50264376
Substrate
n/a
Meas. Tech.
ChEMBL_534971 (CHEMBL986333)
Ki
98.9±n/a nM
Citation
 Mamolo, MG; Zampieri, D; Zanette, C; Florio, C; Collina, S; Urbano, M; Azzolina, O; Vio, L Substituted benzylaminoalkylindoles with preference for the sigma2 binding site. Eur J Med Chem 43:2073-81 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50264376
Synonyms:
CHEMBL484258 | N-(3-Chlorobenzyl)-3-[1-(4-fluorophenyl)-1H-indol-3-yl]-N-methylpropan-1-amine
Type:
Small organic molecule
Emp. Form.:
C25H24ClFN2
Mol. Mass.:
406.923
SMILES:
CN(CCCc1cn(-c2ccc(F)cc2)c2ccccc12)Cc1cccc(Cl)c1
Structure:
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