Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50280521
Substrate
n/a
Meas. Tech.
ChEMBL_140095 (CHEMBL752972)
Kd
1210±n/a nM
Citation
 Kozikowski, AP; Fauq, AH; Miller, JH; McKinney, M Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine. Bioorg Med Chem Lett 2:797-802 (1992)    Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50280521
Synonyms:
(4R,5S)-5-Methyl-4-[(E)-3-((R)-1-methyl-piperidin-2-yl)-allyl]-dihydro-furan-2-one | CHEMBL22923
Type:
Small organic molecule
Emp. Form.:
C14H23NO2
Mol. Mass.:
237.3379
SMILES:
C[C@@H]1OC(=O)C[C@H]1C\C=C\[C@H]1CCCCN1C
Structure:
Search PDB for entries with ligand similarity: