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Target
Kappa-type opioid receptor
Ligand
BDBM50018784
Substrate
n/a
Meas. Tech.
ChEBML_147220
Ki
29±n/a nM
Citation
 Clark, CR; Halfpenny, PR; Hill, RG; Horwell, DC; Hughes, J; Jarvis, TC; Rees, DC; Schofield, D Highly selective kappa opioid analgesics. Synthesis and structure-activity relationships of novel N-[(2-aminocyclohexyl)aryl]acetamide and N-[(2-aminocyclohexyl)aryloxy]acetamide derivatives. J Med Chem 31:831-6 (1988) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50018784
Synonyms:
CHEMBL559217 | N-(2-Azepan-1-yl-cyclohexyl)-2-benzofuran-4-yl-N-methyl-acetamide; hydrochloride
Type:
Small organic molecule
Emp. Form.:
C23H32N2O2
Mol. Mass.:
368.5124
SMILES:
CN([C@@H]1CCCC[C@H]1N1CCCCCC1)C(=O)Cc1cccc2occc12
Structure:
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