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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50095395
Substrate
n/a
Meas. Tech.
ChEMBL_470479 (CHEMBL951323)
IC50
18000±n/a nM
Citation
 Zhu, T; Jiao, Y; Chen, YD; Wang, X; Li, HF; Zhang, LY; Lu, T Pharmacophore identification of Raf-1 kinase inhibitors. Bioorg Med Chem Lett 18:2346-50 (2008) [PubMed]  Article 
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50095395
Synonyms:
3-[3-(4-Amino-phenyl)-ureido]-5-tert-butyl-thiophene-2-carboxylic acid methyl ester | CHEMBL18942 | methyl 3-(3-(4-aminophenyl)ureido)-5-tert-butylthiophene-2-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H21N3O3S
Mol. Mass.:
347.432
SMILES:
COC(=O)c1sc(cc1NC(=O)Nc1ccc(N)cc1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: