Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50274972
Substrate
n/a
Meas. Tech.
ChEMBL_496151 (CHEMBL1000140)
Ki
177±n/a nM
Citation
 Berardi, F; Abate, C; Ferorelli, S; de Robertis, AF; Leopoldo, M; Colabufo, NA; Niso, M; Perrone, R Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. J Med Chem 51:7523-31 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50274972
Synonyms:
4-[1-(2,6-Dimethylphenyl)-3-cyclohexen-4-yl]-1-(2-pyridinyl)piperazine | CHEMBL457731
Type:
Small organic molecule
Emp. Form.:
C23H29N3
Mol. Mass.:
347.4965
SMILES:
Cc1cccc(C)c1C1=CCC(CC1)N1CCN(CC1)c1ccccn1 |t:9|
Structure:
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