Reaction Details Report a problem with these data
Target
Beta-2 adrenergic receptor
Ligand
BDBM50313921
Substrate
n/a
Meas. Tech.
ChEMBL_615505 (CHEMBL1105983)
IC50
>10000±n/a nM
Citation
 Goble, SD; Wang, L; Howell, KL; Bansal, A; Berger, R; Brockunier, L; DiSalvo, J; Feighner, S; Harper, B; He, J; Hurley, A; Hreniuk, D; Parmee, E; Robbins, M; Salituro, G; Sanfiz, A; Streckfuss, E; Watkins, E; Weber, AE; Struthers, M; Edmondson, SD Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles. Bioorg Med Chem Lett 20:1895-9 (2010) [PubMed]  Article 
Target
Name:
Beta-2 adrenergic receptor
Synonyms:
ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor
Type:
n/a
Mol. Mass.:
46461.69
Organism:
Homo sapiens (Human)
Description:
P07550
Residue:
413
Sequence:
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRFHVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNTGEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
  
Inhibitor
Name:
BDBM50313921
Synonyms:
(R)-N-(4-(2-(2-hydroxy-2-(pyridin-3-yl)ethylamino)ethyl)phenyl)-2-(4-oxoquinazolin-3(4H)-yl)acetamide | CHEMBL1077238
Type:
Small organic molecule
Emp. Form.:
C25H25N5O3
Mol. Mass.:
443.4977
SMILES:
O[C@@H](CNCCc1ccc(NC(=O)Cn2cnc3ccccc3c2=O)cc1)c1cccnc1 |r|
Structure:
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