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Target
Aurora kinase B
Ligand
BDBM50379352
Substrate
n/a
Meas. Tech.
ChEMBL_811982 (CHEMBL2013352)
IC50
24±n/a nM
Citation
 Wang, T; Block, MA; Cowen, S; Davies, AM; Devereaux, E; Gingipalli, L; Johannes, J; Larsen, NA; Su, Q; Tucker, JA; Whitston, D; Wu, J; Zhang, HJ; Zinda, M; Chuaqui, C Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKe kinases. Bioorg Med Chem Lett 22:2063-9 (2012) [PubMed]  Article 
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50379352
Synonyms:
CHEMBL2011928
Type:
Small organic molecule
Emp. Form.:
C18H20BrN5O2
Mol. Mass.:
418.288
SMILES:
COc1ccc(cc1)-c1nc2ncc(Br)c(NCCCNC(C)=O)c2[nH]1
Structure:
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