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Target
Homoserine kinase
Ligand
BDBM85126
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
pH
7.5±0
Temperature
310.15±0 K
Ki
8.6e+3± 4e+2 nM
Citation
 De Pascale, G; Griffiths, EJ; Shakya, T; Nazi, I; Wright, GD Identification and characterization of new inhibitors of fungal homoserine kinase. Chembiochem 12:1179-82 (2011) [PubMed]  Article 
Target
Name:
Homoserine kinase
Synonyms:
KHSE_ECOLI | thrB
Type:
Enzyme
Mol. Mass.:
33619.26
Organism:
Escherichia coli
Description:
P00547
Residue:
310
Sequence:
MVKVYAPASSANMSVGFDVLGAAVTPVDGALLGDVVTVEAAETFSLNNLGRFADKLPSEPRENIVYQCWERFCQELGKQIPVAMTLEKNMPIGSGLGSSACSVVAALMAMNEHCGKPLNDTRLLALMGELEGRISGSIHYDNVAPCFLGGMQLMIEENDIISQQVPGFDEWLWVLAYPGIKVSTAEARAILPAQYRRQDCIAHGRHLAGFIHACYSRQPELAAKLMKDVIAEPYRERLLPGFRQARQAVAEIGAVASGISGSGPTLFALCDKPETAQRVADWLGKNYLQNQEGFVHICRLDTAGARVLEN
  
Inhibitor
Name:
BDBM85126
Synonyms:
Thr1 inhibitor, 6
Type:
Small organic molecule
Emp. Form.:
C14H12F3N3O
Mol. Mass.:
295.2598
SMILES:
CC1NN(c2nc(cc(O)c12)C(F)(F)F)c1ccccc1
Structure:
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