Reaction Details
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Report a problem with these dataTarget
Thromboxane A2 receptor
Ligand
BDBM670949
Substrate
n/a
Ki
3.1±n/a nM
Comments
PDSP_4502
Citation
Hanson, J; Rolin, S; Reynaud, D; Qiao, N; Kelley, LP; Reid, HM; Valentin, F; Tippins, J; Kinsella, BT; Masereel, B; Pace-Asciak, C; Pirotte, B; Dogné, JM In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist. J Pharmacol Exp Ther 313:293-301 (2005) [PubMed] Article More Info.:
Target
Name:
Isoform 2 of Thromboxane A2 receptor
Synonyms:
Thromboxane Beta
Type:
Enzyme
Mol. Mass.:
44219.96
Organism:
Human
Description:
P21731-2
Residue:
407
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRRSLTLWPSLEYSGTISAHCNLRLPGSSDSRASASRAAGITGVSHCARPCMLFDPEFDLLAGVQLLPFEPPTGKALSRKD
Inhibitor
Name:
BDBM670949
Synonyms:
BDBM50188614 | BM-513
Type:
n/a
Emp. Form.:
C19H24N4O5S
Mol. Mass.:
420.483
SMILES:
CCCCCNC(=O)NS(=O)(=O)c1cc(ccc1Nc1ccc(C)cc1)[N+]([O-])=O
Structure:
