Reaction Details Report a problem with these data
Target
Beta-galactosidase [24-677,R201C]
Ligand
BDBM228800
Substrate
4-Methylumbelliferyl-β-D-galactopyranoside
Meas. Tech.
β-Gal Inhibitory Assay
pH
4.5±n/a
Temperature
310.15±n/a K
Ki
9.4e+2±n/a nM
Citation
Suzuki, H; Ohto, U; Higaki, K; Mena-Barragán, T; Aguilar-Moncayo, M; Ortiz Mellet, C; Nanba, E; Garcia Fernandez, JM; Suzuki, Y; Shimizu, T Structural basis of pharmacological chaperoning for human ß-galactosidase. J Biol Chem 289:14560-8 (2014) [PubMed] Article
More Info.:
Target
Name:
Beta-galactosidase [24-677,R201C]
Synonyms:
BGAL_HUMAN | ELNR1 | GLB1 | beta-Galactosidase ( -Gal)(R201C)
Type:
Enzyme
Mol. Mass.:
73534.19
Organism:
Human
Description:
Human β-Gal (24-677 aa) with R201C mutation
Residue:
654
Sequence:
LRNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLCFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
Inhibitor
Name:
BDBM228800
Synonyms:
NOEV | Sapienic acid (SpA)
Type:
Small organic molecule
Emp. Form.:
C15H29NO4
Mol. Mass.:
287.3951
SMILES:
CCCCCCCCN[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O |t:10|