Reaction Details Report a problem with these data
Target
Beta-galactosidase [24-677,I51T]
Ligand
BDBM228802
Substrate
4-Methylumbelliferyl-β-D-galactopyranoside
Meas. Tech.
β-Gal Inhibitory Assay
pH
4.5±n/a
Temperature
310.15±n/a K
Ki
6.88e+4±n/a nM
Citation
Suzuki, H; Ohto, U; Higaki, K; Mena-Barragán, T; Aguilar-Moncayo, M; Ortiz Mellet, C; Nanba, E; Garcia Fernandez, JM; Suzuki, Y; Shimizu, T Structural basis of pharmacological chaperoning for human ß-galactosidase. J Biol Chem 289:14560-8 (2014) [PubMed] Article
More Info.:
Target
Name:
Beta-galactosidase [24-677,I51T]
Synonyms:
BGAL_HUMAN | ELNR1 | GLB1 | beta-Galactosidase ( -Gal)(I51T)
Type:
Enzyme
Mol. Mass.:
73576.18
Organism:
Human
Description:
Human β-Gal (24-677 aa) with I51T mutation
Residue:
654
Sequence:
LRNATQRMFEIDYSRDSFLKDGQPFRYTSGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVRSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV
Inhibitor
Name:
BDBM228802
Synonyms:
5N,6S-(N'-butyliminomethylidene)-6-thio-1-deoxygalactonojirimycin | 6S-NBI-DGJ
Type:
Small organic molecule
Emp. Form.:
C11H20N2O3S
Mol. Mass.:
260.353
SMILES:
CCCC\N=C1/SC[C@@H]2[C@H](O)[C@H](O)[C@@H](O)CN12