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Target
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Ligand
BDBM434178
Substrate
n/a
Meas. Tech.
Enzymatic Inhibition Assay
IC50
<1000±n/a nM
Citation
 Schenkel, LB; Vasbinder, MM; Kuntz, KW; Swinger, KK Quinazolinones as PARP14 inhibitors US Patent  US10562891 Publication Date 2/18/2020 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP14 [1611-1801]
Synonyms:
BAL2 | KIAA1268 | PAR14_HUMAN | PARP14 | Protein mono-ADP-ribosyltransferase PARP14 (aa 1611-1801)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21749.94
Organism:
Homo sapiens (Human)
Description:
aa 1611-1801
Residue:
190
Sequence:
DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFVAFYDYQAYPEYLITFR
  
Inhibitor
Name:
BDBM434178
Synonyms:
US10562891, Example 100 | US11008308, Example 100
Type:
Small organic molecule
Emp. Form.:
C20H22N4O2S
Mol. Mass.:
382.479
SMILES:
O[C@H]1CC[C@H](CC1)SCc1nc2cc(Nc3cccnc3)ccc2c(=O)[nH]1 |r,wU:4.7,1.0,(9.34,1.57,;8,2.34,;6.67,1.57,;5.33,2.34,;5.33,3.88,;6.67,4.65,;8,3.88,;4,4.65,;2.67,3.88,;1.33,4.65,;,3.88,;-1.33,4.65,;-2.67,3.88,;-4,4.65,;-5.33,3.88,;-6.67,4.65,;-8,3.88,;-9.34,4.65,;-9.34,6.19,;-8,6.96,;-6.67,6.19,;-4,6.19,;-2.67,6.96,;-1.33,6.19,;,6.96,;,8.5,;1.33,6.19,)|
Structure:
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