Reaction Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Ligand
BDBM399927
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
2.00±n/a nM
Citation
Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Hayward, MM 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds US Patent US10738063 Publication Date 8/11/2020 More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Synonyms:
DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92170.87
Organism:
Homo sapiens (Human)
Description:
aa 2-825
Residue:
824
Sequence:
EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
Inhibitor
Name:
BDBM399927
Synonyms:
(6S)-3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropyl-6-fluoro-6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide | US10323042, Example 7 | US10738063, Example 7
Type:
Small organic molecule
Emp. Form.:
C16H13ClF3N3O2
Mol. Mass.:
371.742
SMILES:
F[C@@H]1COc2c(c(nn2C1)C(=O)NC1CC1)-c1cc(F)c(Cl)cc1F |r,wD:1.0,(-5.04,-16.18,;-3.71,-15.41,;-3.71,-13.87,;-2.37,-13.1,;-1.04,-13.87,;.42,-13.4,;1.33,-14.64,;.42,-15.89,;-1.04,-15.41,;-2.37,-16.18,;2.87,-14.64,;3.64,-13.31,;3.64,-15.97,;5.18,-15.97,;6.51,-16.74,;6.51,-15.2,;.82,-11.91,;2.31,-11.51,;2.71,-10.02,;4.2,-9.62,;1.62,-8.93,;2.02,-7.44,;.13,-9.33,;-.27,-10.82,;-1.75,-11.22,)|
Structure:
