Reaction Details
Report a problem with these data
Report a problem with these dataTarget
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Ligand
BDBM399973
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA)
IC50
6.45±n/a nM
Citation
Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Hayward, MM 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds US Patent US10738063 Publication Date 8/11/2020 More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825]
Synonyms:
DPDE2 | PDE4A | PDE4A_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase (PDE4A3) (2-825)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
92170.87
Organism:
Human
Description:
aa 2-825
Residue:
824
Sequence:
EPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWR
Inhibitor
Name:
BDBM399973
Synonyms:
US10323042, Example 53A | US10323042, Example 53B | US10738063, Example 53B
Type:
Small organic molecule
Emp. Form.:
C18H16F2N4O2
Mol. Mass.:
358.342
SMILES:
Cc1cc(C#N)c(F)cc1-c1c(nn2C[C@H](F)COc12)C(=O)NC1CC1 |r,wD:15.16,(-2.49,.13,;-1,.53,;-.6,2.02,;.9,2.47,;1.3,3.96,;1.7,5.45,;1.97,1.33,;3.46,1.73,;1.57,-.16,;.09,-.56,;-.31,-2.04,;.59,-3.29,;-.31,-4.54,;-1.78,-4.06,;-3.11,-4.83,;-4.44,-4.06,;-5.78,-4.83,;-4.44,-2.52,;-3.11,-1.75,;-1.78,-2.52,;2.13,-3.29,;2.9,-1.96,;2.9,-4.62,;4.44,-4.62,;5.78,-5.39,;5.78,-3.85,)|
Structure:
