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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Ligand
BDBM424936
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
140±n/a nM
Citation
 Kehler, J; Juhl, K; Marigo, M; Vital, PJ; Jessing, M; Langgård, M; Rasmussen, LK; Clementson, CM 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors US Patent  US11026923 Publication Date 6/8/2021 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Synonyms:
61 kDa Cam-PDE | Calcium/calmodulin-dependent 3',5'-cyclic phosphodiesterase 1A | Cam-PDE 1A | PDE1A | PDE1A_HUMAN | hCam-1
Type:
Protein
Mol. Mass.:
61245.69
Organism:
Homo sapiens (Human)
Description:
P54750
Residue:
535
Sequence:
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQEARTSSQKCEFIHQ
  
Inhibitor
Name:
BDBM424936
Synonyms:
US10512632, Example 26 | US10618913, Example S26 | US10766893, Example S26 | US10806718, Example 26 | US11026923, Example 26 | US11491140, Example 26 | US11634416, Example 26
Type:
Small organic molecule
Emp. Form.:
C20H23N7O
Mol. Mass.:
377.4429
SMILES:
CCOc1ncccc1-c1cc(NCc2cnn(C)c2)c2n(CC)ncc2n1
Structure:
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