Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM511708
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Barrish, JC; Greenlee, W; Eastman, KJ Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders US Patent  US11084800 Publication Date 8/10/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM511708
Synonyms:
(3S)-5-(2-azaspiro[3.3]heptan-2-ylmethyl)-2- (2-(3-acetyl-5-(2-methylpyrimidin-5-yl)-1H- indazol-1-yl)acetyl)-N-(6-bromo-3- methylpyridin-2-yl)-2- azabicyclo[3.1.0]hexane-3-carboxamide | US11084800, Cpd No. 13 | US11708351, Compound 13
Type:
Small organic molecule
Emp. Form.:
C35H37BrN8O3
Mol. Mass.:
697.624
SMILES:
CC(=O)c1nn(CC(=O)N2C3CC3(CN3CC4(CCC4)C3)C[C@H]2C(=O)Nc2nc(Br)ccc2C)c2ccc(cc12)-c1cnc(C)nc1 |r|
Structure:
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