Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM511713
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Barrish, JC; Greenlee, W; Eastman, KJ Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders US Patent  US11084800 Publication Date 8/10/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM511713
Synonyms:
(1R,3S,5R)-2-(2-(3-acetyl-7-methyl-5-(2- methylpyrimidin-5-yl)-1H-indazol-1- yl)acetyl)-N-(6-bromopyridin-2-yl)-5-methyl- 2-azabicyclo[3.1.0]hexane-3-carboxamide | US11084800, Cpd No. 18 | US11708351, Compound 336
Type:
Small organic molecule
Emp. Form.:
C29H28BrN7O3
Mol. Mass.:
602.482
SMILES:
CC(=O)c1nn(CC(=O)N2[C@@H]3C[C@]3(C)C[C@H]2C(=O)Nc2cccc(Br)n2)c2c(C)cc(cc12)-c1cnc(C)nc1 |r|
Structure:
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