Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM511718
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Barrish, JC; Greenlee, W; Eastman, KJ Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders US Patent US11084800 Publication Date 8/10/2021
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM511718
Synonyms:
(2S,4R)-1-(2-(3-acetyl-5-(2-methylpyrimidin- 5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromo-3- (cyanomethyl)pyridin-2-yl)-4- fluoropyrrolidine-2-carboxamide | US11084800, Cpd No. 23 | US11708351, Compound 23
Type:
Small organic molecule
Emp. Form.:
C28H24BrFN8O3
Mol. Mass.:
619.444
SMILES:
CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2nc(Br)ccc2CC#N)c2ccc(cc12)-c1cnc(C)nc1 |r|