Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM511719
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Barrish, JC; Greenlee, W; Eastman, KJ Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders US Patent US11084800 Publication Date 8/10/2021
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM511719
Synonyms:
(3S)-2-(2-(3-acetyl-5-(2- methylpyrimidin-5-yl)-1H-indazol-1- yl)acetyl)-N-(6-bromo-3-methylpyridin-2- yl)-5-((4-methylpiperazin-1-yl)methyl)-2- azabicyclo[3.1.0]hexane-3-carboxamide | US11084800, Cpd No. 24 | US11708351, Compound 24
Type:
Small organic molecule
Emp. Form.:
C34H38BrN9O3
Mol. Mass.:
700.628
SMILES:
CN1CCN(CC23CC2N([C@@H](C3)C(=O)Nc2nc(Br)ccc2C)C(=O)Cn2nc(C(C)=O)c3cc(ccc23)-c2cnc(C)nc2)CC1 |r|