Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM511743
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Barrish, JC; Greenlee, W; Eastman, KJ Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders US Patent US11084800 Publication Date 8/10/2021
More Info.:
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
Inhibitor
Name:
BDBM511743
Synonyms:
(3S)-2-(2-(3-acetyl-5-(2-methylpyrimidin-5- yl)-1H-indazol-1-yl)acetyl)-N-(3-bromo-6- (methoxymethyl)pyridin-2-yl)-5- (methoxymethyl)-2-azabicyclo[3.1.0]hexane- 3-carboxamide | US11084800, Cpd No. 49 | US11708351, Compound 49
Type:
Small organic molecule
Emp. Form.:
C31H32BrN7O5
Mol. Mass.:
662.534
SMILES:
COCc1ccc(Br)c(NC(=O)[C@@H]2CC3(COC)CC3N2C(=O)Cn2nc(C(C)=O)c3cc(ccc23)-c2cnc(C)nc2)n1 |r|