Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM511748
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
<1000±n/a nM
Citation
 Wiles, JA; Phadke, AS; Deshpande, M; Agarwal, A; Chen, D; Gadhachanda, VR; Hashimoto, A; Pais, G; Wang, Q; Wang, X; Barrish, JC; Greenlee, W; Eastman, KJ Aryl, heteroaryl, and heterocyclic pharmaceutical compounds for treatment of medical disorders US Patent  US11084800 Publication Date 8/10/2021 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM511748
Synonyms:
1-(2-((1R,2S,5S)-2-((6-bromo-3- methylpyridin-2-yl)carbamoyl)-3- azabicyclo[3.1.0]hexan-3-yl)-2-oxoethyl)-5- (2-methylpyrimidin-5-yl)-1H-indazole-3- carboxamide | US11084800, Cpd No. 56 | US11708351, Compound 56
Type:
Small organic molecule
Emp. Form.:
C27H25BrN8O3
Mol. Mass.:
589.443
SMILES:
Cc1ncc(cn1)-c1ccc2n(CC(=O)N3C[C@H]4C[C@H]4[C@H]3C(=O)Nc3nc(Br)ccc3C)nc(C(N)=O)c2c1 |r|
Structure:
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