Reaction Details Report a problem with these data
Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM517310
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
IC50
3.30±n/a nM
Citation
 Shen, D; Graham, TH; Liu, W; Tudge, C; Verras, A; Jiang, J Indazole derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 US Patent  US11104690 Publication Date 8/31/2021 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM517310
Synonyms:
3-[3-(difluoromethoxy)phenyl]-1- (5-fluoropyridin-2-yl)-N-(3- methyl-1,1- dioxidotetrahydrothiophen-3-yl)- 1H-indazole-6-carboxamide (enantiomer A) | US11104690, Example 128-A
Type:
Small organic molecule
Emp. Form.:
C25H21F3N4O4S
Mol. Mass.:
530.519
SMILES:
C[C@]1(CCS(=O)(=O)C1)NC(=O)c1ccc2c(nn(-c3ccc(F)cn3)c2c1)-c1cccc(OC(F)F)c1 |r|
Structure:
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