Reaction Details Report a problem with these data
Target
MAPK/MAK/MRK overlapping kinase
Ligand
BDBM528540
Substrate
n/a
Meas. Tech.
Fluorescence Binding Assay
Kd
34.0±n/a nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Quinoline compounds as modulators of RAGE activity and uses thereof US Patent  US11192859 Publication Date 12/7/2021 
Target
Name:
MAPK/MAK/MRK overlapping kinase
Synonyms:
2.7.11.22 | MAPK/MAK/MRK overlapping kinase | MOK | MOK protein kinase | MOK_HUMAN | RAGE | RAGE-1 | RAGE1 | Renal tumor antigen 1
Type:
PROTEIN
Mol. Mass.:
48045.51
Organism:
Homo sapiens
Description:
ChEMBL_118228
Residue:
419
Sequence:
MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR
  
Inhibitor
Name:
BDBM528540
Synonyms:
US11192859, Compound 221
Type:
Small organic molecule
Emp. Form.:
C22H24N4O2
Mol. Mass.:
376.4516
SMILES:
NCC(=O)Nc1ccc(cc1)-c1cc(CN2CCOCC2)c2ccccc2n1
Structure:
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