Reaction Details Report a problem with these data
Target
MAPK/MAK/MRK overlapping kinase
Ligand
BDBM528554
Substrate
n/a
Meas. Tech.
Fluorescence Binding Assay
Kd
11.0±n/a nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Quinoline compounds as modulators of RAGE activity and uses thereof US Patent  US11192859 Publication Date 12/7/2021 
Target
Name:
MAPK/MAK/MRK overlapping kinase
Synonyms:
2.7.11.22 | MAPK/MAK/MRK overlapping kinase | MOK | MOK protein kinase | MOK_HUMAN | RAGE | RAGE-1 | RAGE1 | Renal tumor antigen 1
Type:
PROTEIN
Mol. Mass.:
48045.51
Organism:
Homo sapiens
Description:
ChEMBL_118228
Residue:
419
Sequence:
MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR
  
Inhibitor
Name:
BDBM528554
Synonyms:
US11192859, Compound 241
Type:
Small organic molecule
Emp. Form.:
C21H24N4O
Mol. Mass.:
348.4415
SMILES:
CNCCNCc1cc(nc2ccccc12)-c1ccc(NC(C)=O)cc1
Structure:
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