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Target
MAPK/MAK/MRK overlapping kinase
Ligand
BDBM528556
Substrate
n/a
Meas. Tech.
Fluorescence Binding Assay
Kd
54.0±n/a nM
Citation
 Schmidt, AM; Ramasamy, R; Shekhtman, A; Rai, V; Manigrasso, MB Quinoline compounds as modulators of RAGE activity and uses thereof US Patent  US11192859 Publication Date 12/7/2021 
Target
Name:
MAPK/MAK/MRK overlapping kinase
Synonyms:
2.7.11.22 | MAPK/MAK/MRK overlapping kinase | MOK | MOK protein kinase | MOK_HUMAN | RAGE | RAGE-1 | RAGE1 | Renal tumor antigen 1
Type:
PROTEIN
Mol. Mass.:
48045.51
Organism:
Homo sapiens
Description:
ChEMBL_118228
Residue:
419
Sequence:
MKNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKPENILIKQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGRKQKQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRPLKCIPASKKTDPQKDLKPAPQQCRLPTIVRKGGR
  
Inhibitor
Name:
BDBM528556
Synonyms:
US11192859, Compound 244
Type:
Small organic molecule
Emp. Form.:
C27H31N4O3
Mol. Mass.:
459.5606
SMILES:
CC(=O)Nc1ccc(cc1)-c1cc(CN2CCN(C(C2)C(C)(C)C)C([O-])=O)c2ccccc2n1
Structure:
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