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Target
Lysine-specific histone demethylase 1A
Ligand
BDBM534963
Substrate
n/a
Meas. Tech.
Biological Activity Assay
IC50
4000±n/a nM
Citation
 Rienhoff, Jr., HY; McCall, JM; Clare, M; Celatka, C; Tapper, AE KDM1A inhibitors for the treatment of disease US Patent  US11230534 Publication Date 1/25/2022 
Target
Name:
Lysine-specific histone demethylase 1A
Synonyms:
AOF2 | BRAF35-HDAC complex protein BHC110 | Flavin-containing amine oxidase domain-containing protein 2 | KDM1 | KDM1A | KDM1A_HUMAN | KIAA0601 | LSD1 | Lysine-specific demethylase 1 (LSD1) | Lysine-specific histone demethylase 1 | Lysine-specific histone demethylase 1 (LSD1)
Type:
Enzyme
Mol. Mass.:
92901.01
Organism:
Homo sapiens (Human)
Description:
O60341
Residue:
852
Sequence:
MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQPAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPTKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
  
Inhibitor
Name:
BDBM534963
Synonyms:
4'-fluoro-N-((S)-4-((1R,2S)-2-(4- fluorophenyl)cyclopropylamino)-1- oxo-1-(thiomorpholino-4,4-dioxide- 1-yl)-butan-2-yl)biphenyl-4- carboxamide | US11230534, Example 187
Type:
Small organic molecule
Emp. Form.:
C30H31F2N3O4S
Mol. Mass.:
567.647
SMILES:
Fc1ccc(cc1)[C@@H]1C[C@H]1NCC[C@H](NC(=O)c1ccc(cc1)-c1ccc(F)cc1)C(=O)N1CCS(=O)(=O)CC1 |r,$;;;;;;;;;;N;;;;;;;;;;;;;;;;;;;;;;;;;S;;;;$|
Structure:
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