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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445086
Substrate
n/a
Meas. Tech.
USP30 Biochemical IC50 Assay
IC50
550±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US11319287 Publication Date 5/3/2022 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445086
Synonyms:
(S)-2-(4-(3,5-dimethyl- 1H-pyrazol-4-yl)indoline- 1-carbonyl)pyrrolidine- 1-carbonitrile | US10669234, Example 25 | US11319287, Example 25
Type:
Small organic molecule
Emp. Form.:
C19H21N5O
Mol. Mass.:
335.4029
SMILES:
Cc1n[nH]c(C)c1-c1cccc2N(CCc12)C(=O)[C@@H]1CCCN1C#N |wU:18.20,(4.04,-2.74,;2.58,-3.22,;2.1,-4.68,;.56,-4.68,;.09,-3.22,;-1.38,-2.74,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;1.33,2.31,;,1.54,;-1.46,2.02,;-2.37,.77,;-1.46,-.48,;;-1.94,3.48,;-3.45,3.8,;-.91,4.63,;.62,4.46,;1.25,5.87,;.1,6.9,;-1.23,6.13,;-2.64,6.76,;-4.04,7.38,)|
Structure:
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