Reaction Details Report a problem with these data
Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM552973
Substrate
n/a
Meas. Tech.
USP30 Biochemical IC50 Assay
IC50
550±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US11319287 Publication Date 5/3/2022 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM552973
Synonyms:
(S)-4,4-difluoro-2-(4-(5- | US11319287, Example 28
Type:
Small organic molecule
Emp. Form.:
C18H14F5N5O
Mol. Mass.:
411.3287
SMILES:
FC(F)(F)c1n[nH]cc1-c1cccc2N(CCc12)C(=O)[C@@H]1CC(F)(F)CN1C#N
Structure:
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