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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Ligand
BDBM445107
Substrate
n/a
Meas. Tech.
USP30 Biochemical IC50 Assay
IC50
550±n/a nM
Citation
 Kemp, M; Stockley, M; Jones, A Cyanopyrrolidines as dub inhibitors for the treatment of cancer US Patent  US11319287 Publication Date 5/3/2022 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms:
Neuron cytoplasmic protein 9.5 | PGP 9.5 | PGP9.5 | UCH-L1 | UCHL1 | UCHL1_HUMAN | Ubiquitin thioesterase L1
Type:
PROTEIN
Mol. Mass.:
24819.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_974327
Residue:
223
Sequence:
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSETEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
  
Inhibitor
Name:
BDBM445107
Synonyms:
(S)-1-Cyano-N-(4-(2-methoxyphenyl)thiazol-2-yl)-N-methylpyrrolidine-2-carboxamide | US10669234, Example 46 | US11319287, Example 46
Type:
Small organic molecule
Emp. Form.:
C17H18N4O2S
Mol. Mass.:
342.415
SMILES:
COc1ccccc1-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N |r|
Structure:
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