Reaction Details Report a problem with these data
Target
Protein mono-ADP-ribosyltransferase PARP6
Ligand
BDBM553940
Substrate
n/a
Meas. Tech.
Fluorescence Anisotropy Binding Assay
IC50
19000±n/a nM
Citation
 Johannes, JW; Hande, SM; Degorce, SL; Packer, MJ Chemical compounds US Patent  US11325906 Publication Date 5/10/2022 
Target
Name:
Protein mono-ADP-ribosyltransferase PARP6
Synonyms:
ADP-ribosyltransferase diphtheria toxin-like 17 | ARTD17 | PARP-6 | PARP6 | PARP6_HUMAN | Poly [ADP-ribose] polymerase 6
Type:
PROTEIN
Mol. Mass.:
71130.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107589
Residue:
630
Sequence:
MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADIEAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSLSQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSWFKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMKNPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAEQRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEVVDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSIREMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLSSPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIYLSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIALCEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIGTQVYTN
  
Inhibitor
Name:
BDBM553940
Synonyms:
US11325906, Example 4
Type:
Small organic molecule
Emp. Form.:
C22H26N6O2
Mol. Mass.:
406.4808
SMILES:
CCc1cc2ncc(CN3CCN(CC3)c3ccc(nc3)C(=O)NC)cc2[nH]c1=O
Structure:
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