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Target
Serine/threonine-protein kinase B-raf [V600K]
Ligand
BDBM565127
Substrate
n/a
Meas. Tech.
BRAF V600E and V600K Enzyme Assay
IC50
8.10±n/a nM
Citation
 Barbour, PM; Brown, KK; Cook, AW; Hicken, EJ; Kahn, DR; Laird, ER; Metcalf, AT; Moreno, DA; Newhouse, BJ; Pajk, SP; Prigaro, BJ; Ren, L; Tarlton, E Compounds for the treatment of BRAF-associated diseases and disorders US Patent  US11414404 Publication Date 8/16/2022 
Target
Name:
Serine/threonine-protein kinase B-raf [V600K]
Synonyms:
BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | Serine/threonine-protein kinase B-raf (V600K)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
84476.05
Organism:
Homo sapiens (Human)
Description:
P15056[V600K]
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATKKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM565127
Synonyms:
US11414404, Ex. # 4 | US11634409, Example 4
Type:
Small organic molecule
Emp. Form.:
C19H20ClFN4O3S
Mol. Mass.:
438.904
SMILES:
Cc1c(Nc2cccc(NS(=O)(=O)CCCF)c2Cl)ccc2ncn(C)c(=O)c12
Structure:
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