Reaction Details Report a problem with these data
Target
N-glycosylase/DNA lyase
Ligand
BDBM570791
Substrate
n/a
Meas. Tech.
OGG1 Inhibitor Assays
IC50
1500±n/a nM
Citation
 Kool, ET; Tahara, Y Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity US Patent  US11440887 Publication Date 9/13/2022 
Target
Name:
N-glycosylase/DNA lyase
Synonyms:
8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1
Type:
Protein
Mol. Mass.:
38794.33
Organism:
Homo sapiens (Human)
Description:
O15527
Residue:
345
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
  
Inhibitor
Name:
BDBM570791
Synonyms:
US11440887, Compound 28
Type:
Small organic molecule
Emp. Form.:
C25H24N2O4S
Mol. Mass.:
448.534
SMILES:
O=C(C1CC1)N1CCCc2ccc(NS(=O)(=O)c3ccc(Oc4ccccc4)cc3)cc12
Structure:
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