Reaction Details Report a problem with these data
Target
N-glycosylase/DNA lyase
Ligand
BDBM570794
Substrate
n/a
Meas. Tech.
OGG1 Inhibitor Assays
IC50
59.0±n/a nM
Citation
 Kool, ET; Tahara, Y Substituted 1,2,3,4-tetrahydroquinolines as inhibitors of repair enzyme 8-oxoguanine deoxyribonucleic acid glycosylase activity US Patent  US11440887 Publication Date 9/13/2022 
Target
Name:
N-glycosylase/DNA lyase
Synonyms:
8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1
Type:
Protein
Mol. Mass.:
38794.33
Organism:
Homo sapiens (Human)
Description:
O15527
Residue:
345
Sequence:
MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
  
Inhibitor
Name:
BDBM570794
Synonyms:
US11440887, Compound 41
Type:
Small organic molecule
Emp. Form.:
C26H25N3O4S
Mol. Mass.:
475.559
SMILES:
NC(=O)c1cccc(c1)-c1ccc(cc1)S(=O)(=O)Nc1ccc2CCCN(C(=O)C3CC3)c2c1
Structure:
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