Reaction Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Ligand
BDBM577109
Substrate
n/a
IC50
20.2±n/a nM
Citation
Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Synonyms:
DPDE1 | PDE4C | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C1)(2-712)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79744.34
Organism:
n/a
Description:
aa 2-712
Residue:
711
Sequence:
ENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
Inhibitor
Name:
BDBM577109
Synonyms:
4-(8-Cyclopropyl-9-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-10-yl)-3-fluorobenzonitrile | US11472805, Example 22
Type:
Small organic molecule
Emp. Form.:
C20H15FN4O
Mol. Mass.:
346.3577
SMILES:
Fc1cc(ccc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1)C#N |(-3,.66,;-1.49,.98,;-1.01,2.44,;.51,2.81,;1.52,1.62,;1.05,.15,;-.46,-.17,;-.93,-1.63,;-.03,-2.88,;1.5,-3.04,;2.41,-1.79,;2.13,-4.45,;1.22,-5.69,;-.31,-5.53,;-.93,-4.12,;-2.4,-3.65,;-3.73,-4.42,;-5.07,-3.65,;-5.07,-2.11,;-3.73,-1.34,;-2.4,-2.11,;3.66,-4.61,;4.91,-5.51,;5.07,-3.98,;.99,4.28,;1.46,5.74,)|
Structure:
