Reaction Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Ligand
BDBM577122
Substrate
n/a
IC50
21.0±n/a nM
Citation
Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Synonyms:
DPDE1 | PDE4C | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C1)(2-712)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79744.34
Organism:
n/a
Description:
aa 2-712
Residue:
711
Sequence:
ENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
Inhibitor
Name:
BDBM577122
Synonyms:
4-(7-Cyclopropyl-8-oxo-5,6,7,8-tetrahydro[1,3]thiazolo[4',5':4,5]pyrrolo[1,2-a]pyrazin-9-yl)-2-fluoro-5-methylbenzonitrile | US11472805, Example 28
Type:
Small organic molecule
Emp. Form.:
C19H15FN4OS
Mol. Mass.:
366.412
SMILES:
Cc1cc(C#N)c(F)cc1-c1c2C(=O)N(CCn2c2scnc12)C1CC1 |(-3.15,.66,;-1.65,.98,;-1.17,2.44,;.35,2.81,;.83,4.28,;1.3,5.74,;1.37,1.62,;2.87,1.94,;.89,.15,;-.62,-.17,;-1.09,-1.63,;-.19,-2.88,;1.34,-3.04,;2.25,-1.79,;1.97,-4.45,;1.07,-5.69,;-.47,-5.53,;-1.09,-4.12,;-2.56,-3.65,;-4.02,-4.12,;-4.93,-2.88,;-4.02,-1.63,;-2.56,-2.11,;3.5,-4.61,;4.72,-5.55,;4.93,-4.02,)|
Structure:
