Reaction Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Ligand
BDBM577142
Substrate
n/a
IC50
2.88±n/a nM
Citation
Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Synonyms:
DPDE1 | PDE4C | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C1)(2-712)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79744.34
Organism:
n/a
Description:
aa 2-712
Residue:
711
Sequence:
ENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
Inhibitor
Name:
BDBM577142
Synonyms:
10-(4-Chloro-2-fluorophenyl)-8-cyclopropyl-7,8-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(6H)-one | US11472805, Example 47
Type:
Small organic molecule
Emp. Form.:
C19H15ClFN3O
Mol. Mass.:
355.793
SMILES:
Fc1cc(Cl)ccc1-c1c2C(=O)N(CCn2c2cccnc12)C1CC1 |(-3,1.39,;-1.5,1.71,;-1.02,3.17,;.48,3.49,;.96,4.96,;1.51,2.35,;1.04,.89,;-.47,.57,;-.94,-.9,;-.04,-2.15,;1.49,-2.31,;2.4,-1.06,;2.12,-3.71,;1.21,-4.96,;-.32,-4.8,;-.94,-3.39,;-2.41,-2.92,;-3.74,-3.69,;-5.08,-2.92,;-5.08,-1.38,;-3.74,-.61,;-2.41,-1.38,;3.65,-3.87,;4.87,-4.82,;5.08,-3.29,)|
Structure:
