Reaction Details
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cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Ligand
BDBM577149
Substrate
n/a
IC50
35.8±n/a nM
Citation
Chappie, TA; Patel, NC; Verhoest, PR; Helal, CJ; Sciabola, S; LaChapelle, EA; Wager, TT; Chandrasekaran, RY Tricyclic compounds and their use as phosphodiesterase inhibitors US Patent US11472805 Publication Date 10/18/2022 More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C [2-712]
Synonyms:
DPDE1 | PDE4C | PDE4C_HUMAN | cAMP-specific 3',5'-cyclic phosphodiesterase 4C (PDE4C1)(2-712)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
79744.34
Organism:
n/a
Description:
aa 2-712
Residue:
711
Sequence:
ENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
Inhibitor
Name:
BDBM577149
Synonyms:
8-Cyclopropyl-10-(2-fluoro-4-methoxyphenyl)-7,8-dihydropyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(6H)-one | US11472805, Example 54
Type:
Small organic molecule
Emp. Form.:
C20H18FN3O2
Mol. Mass.:
351.3742
SMILES:
COc1ccc(-c2c3C(=O)N(CCn3c3cccnc23)C2CC2)c(F)c1 |(-.07,5.53,;.96,4.39,;.48,2.92,;1.51,1.78,;1.04,.31,;-.47,-.01,;-.94,-1.47,;-.04,-2.72,;1.49,-2.88,;2.4,-1.63,;2.12,-4.29,;1.21,-5.53,;-.32,-5.37,;-.94,-3.96,;-2.41,-3.49,;-3.74,-4.26,;-5.08,-3.49,;-5.08,-1.95,;-3.74,-1.18,;-2.41,-1.95,;3.65,-4.45,;4.87,-5.39,;5.08,-3.86,;-1.5,1.14,;-3,.82,;-1.02,2.6,)|
Structure:
