Reaction Details
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Mu-type opioid receptor [N127C]
Ligand
BDBM579506
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
320±n/a nM
Citation
Shoichet, BK; Lin, H; Gmeiner, P; Manglik, A; Kobilka, B; Roth, BL; Dengler, DG Mu opioid receptor modulators US Patent US11484525 Publication Date 11/1/2022 More Info.:
Target
Name:
Mu-type opioid receptor [N127C]
Synonyms:
MOR1 | OPRM1 | OPRM_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44778.55
Organism:
Homo sapiens (Human)
Description:
P35372 [N127C]
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVCYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
Inhibitor
Name:
BDBM579506
Synonyms:
US11484525, Compound DD-102
Type:
Small organic molecule
Emp. Form.:
C21H29N3O2
Mol. Mass.:
355.4739
SMILES:
CN(C)[C@H](CNC(=O)N(C)CCc1ccccc1)Cc1ccc(O)cc1 |r|
Structure:
