Reaction Details Report a problem with these data
Target
RAC-alpha serine/threonine-protein kinase [1-472,474-480]
Ligand
BDBM580883
Substrate
n/a
Meas. Tech.
pAKT Protocol
IC50
5190±n/a nM
Citation
 Stocking, EM; Wrasidlo, WJ Tri-substituted aryl and heteroaryl derivatives as modulators of PI3-kinase and autophagy pathways US Patent  US11492348 Publication Date 11/8/2022 
Target
Name:
RAC-alpha serine/threonine-protein kinase [1-472,474-480]
Synonyms:
AKT1 | AKT1_HUMAN | PKB | RAC | pAKT
Type:
Enzyme
Mol. Mass.:
55594.17
Organism:
Homo sapiens (Human)
Description:
P31749[1-472,474-480]
Residue:
479
Sequence:
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFYSASGTA
  
Inhibitor
Name:
BDBM580883
Synonyms:
3-((3-(2-aminopyrimidin-5-yl)-5- morpholinophenyl)sulfonyl)-N,N- dimethylazetidine-1-carboxamide | US11492348, Compound 95
Type:
Small organic molecule
Emp. Form.:
C20H26N6O4S
Mol. Mass.:
446.523
SMILES:
CN(C)C(=O)N1CC(C1)S(=O)(=O)c1cc(cc(c1)-c1cnc(N)nc1)N1CCOCC1
Structure:
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