Reaction Details Report a problem with these data
Target
Kallikrein-6
Ligand
BDBM588057
Substrate
n/a
Meas. Tech.
Activities on KLK6 (Boc-QAR-AMC)
IC50
3740±290 nM
Citation
 El Amri, C; Soualmia, F; Masurier, N; Aït Amiri, S; Nait Oumesmar, B; Deboux, C Compounds and compositions for the treatment of neurodegenerative and inflammatory diseases US Patent  US11541023 Publication Date 1/3/2023 
Target
Name:
Kallikrein-6
Synonyms:
KLK6 | KLK6_HUMAN | Kallikrein 6 | PRSS18 | PRSS9
Type:
PROTEIN
Mol. Mass.:
26861.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_826901
Residue:
244
Sequence:
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
  
Inhibitor
Name:
BDBM588057
Synonyms:
US11541023, Compound 5
Type:
Small organic molecule
Emp. Form.:
C19H18N2O3
Mol. Mass.:
322.3578
SMILES:
COc1ccc2c(O)c(ccc2c1)C(=O)Nc1ccc(CN)cc1
Structure:
Search PDB for entries with ligand similarity: