Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA-directed RNA polymerase subunit beta'
Ligand
BDBM592141
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1800±n/a nM
Citation
Ebright, RH; Ebright, YW; Freundlich, JS; Gallardo-Macias, R; Li, S Antibacterial agents: arylalkylcarboxamido phloroglucinols US Patent US11572337 Publication Date 2/7/2023 More Info.:
Target
Name:
DNA-directed RNA polymerase subunit beta'
Synonyms:
RNA polymerase subunit beta' | RNAP subunit beta' | RPOC_STAAU | Transcriptase subunit beta' | rpoC
Type:
Protein
Mol. Mass.:
118610.70
Organism:
n/a
Description:
P0C1T4
Residue:
1057
Sequence:
MIDVNNFHYMKIGLASPEKIRSWSFGEVKKPETINYRTLKPEKDGLFCERIFGPTKDWECSCGKYKRVRYKGMVCDRCGVEVTKSKVRRERMGHIELAAPVSHIWYFKGIPSRMGLLLDMSPRALEEVIYFASYVVVDPGPTGLEKKTLLSEAEFRDYYDKYPGQFVAKMGAEGIKDLLEEIDLDEELKLLRDELESATGQRLTRAIKRLEVVESFRNSGNKPSWMILDVLPIIPPEIRPMAQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGAPGIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIAVGPSLKMYQCGLPKEMALELFKPFVMKELVQREIATNIKNAKSKIERMDDEVWDVLEEVIREHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVTTAYNADFDGDQMAVHVPLSKEAQAEARMLMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERKDAVNTGAIFNNTNEVLKAYANGFVHLHTRIGVHASSFNNPTFTEEQNKKILATSVGKIIFNEIIPDSFAYINEPTQENLERKTPNRNFIDPTTLGEGGLKEYFENEELIEPFNKKFLGNIIAEVFNRFSITDTSMMLDRMKDLGFKFSSKAGITVGVADIVVLPDKQQILDEHEKLVDRITKQFNRGLITEEERYNAVVEIWTDAKDQIQGELMQSLDKTNPIFMMSDSGARGNASNFTQLAGMRGLMAAPSGKIIELPITSSFREGLTVLEYFISTHGARKGLADTALKTADSGYLTRRLVDVAQDVIVREEDCGTDRGLLVSDIKEGTEMIEPFIERIEGRYSKETIRHPETDEIIIRPDELITPEIAKKITDAGIEQMYIRSAFTCNARHGVCEKCYGKNLATGEKVEVGEAVGTIAAQSIGEPGTQLTMRTFHTGGVAGSDITQGLPRIQEIFEARNPKGQAVITEIEGVVEDIKLAKDRQQEIVVKGANETRSYLASGTSRIIVEIGQPVQRGEVLTEGSIEPKNYLSVAGLNATESYLLKEVQK
Inhibitor
Name:
BDBM592141
Synonyms:
US11572337, Compound 0MTK158
Type:
Small organic molecule
Emp. Form.:
C21H16F3NO5
Mol. Mass.:
419.3506
SMILES:
Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccccc3)cc2C(F)(F)F)c(O)c1
Structure:
