Reaction Details Report a problem with these data
Target
Potassium channel subfamily K member 2
Ligand
BDBM533135
Substrate
n/a
Meas. Tech.
LMPTP Primary Screening Protocol
IC50
500±n/a nM
Citation
Bottini, N; Zou, J; Ganji, SR; Stanford, S; Pinkerton, A; Chung, TD; Hedrick, M; Ardecky, R Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof US Patent US10626094 Publication Date 4/21/2020
More Info.:
Target
Name:
Potassium channel subfamily K member 2
Synonyms:
KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:
Protein
Mol. Mass.:
47099.16
Organism:
Homo sapiens (Human)
Description:
O95069
Residue:
426
Sequence:
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
Inhibitor
Name:
BDBM533135
Synonyms:
US10626094, Example I65 | US11220486, Compound I65 | ethyl 2-[(4-{4-[(3-piperidylpropyl)amino]-2- quinolyl}phenyl)carbonylamino]acetate
Type:
Small organic molecule
Emp. Form.:
C28H34N4O3
Mol. Mass.:
474.5946
SMILES:
CCOC(=O)CNC(=O)c1ccc(cc1)-c1cc(NCCCC2CCCNC2)c2ccccc2n1