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Target
Potassium channel subfamily K member 2
Ligand
BDBM533219
Substrate
n/a
Meas. Tech.
LMPTP Primary Screening Protocol
IC50
500±n/a nM
Citation
 Bottini, N; Zou, J; Ganji, SR; Stanford, S; Pinkerton, A; Chung, TD; Hedrick, M; Ardecky, R Inhibitors of low molecular weight protein tyrosine phosphatase and uses thereof US Patent  US10626094 Publication Date 4/21/2020 
Target
Name:
Potassium channel subfamily K member 2
Synonyms:
KCNK2 | KCNK2_HUMAN | Outward rectifying potassium channel protein TREK-1 | TREK | TREK-1 K(+) channel subunit | TREK1 | Twik-RElated Potassium (K+) channel 1 (TREK1) | Two pore domain potassium channel TREK-1 | Two pore potassium channel TPKC1
Type:
Protein
Mol. Mass.:
47099.16
Organism:
Homo sapiens (Human)
Description:
O95069
Residue:
426
Sequence:
MLPSASRERPGYRAGVAAPDLLDPKSAAQNSKPRLSFSTKPTVLASRVESDTTINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPHEISQRTTIVIQKQTFISQHSCVNSTELDELIQQIVAAINAGIIPLGNTSNQISHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAIIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSIKRKLSAELAGNHNQELTPCRRTLSVNHLTSERDVLPPLLKTESIYLNGLTPHCAGEEIAVIENIK
  
Inhibitor
Name:
BDBM533219
Synonyms:
US10626094, Example I149 | US11220486, Compound I149 | US11220486, Compound I168 | {2-[2,4-bis(trifluoromethyl)phenyl](4- quinolyl)}(3-piperidylpropyl)amine
Type:
Small organic molecule
Emp. Form.:
C25H25F6N3
Mol. Mass.:
481.4765
SMILES:
FC(F)(F)c1ccc(-c2cc(NCCCC3CCCNC3)c3ccccc3n2)c(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: