Reaction Details Report a problem with these data
Target
Casein kinase I isoform alpha
Ligand
BDBM625312
Substrate
n/a
Meas. Tech.
CSNK1A1 1uM ATP Assay
IC50
1.60±n/a nM
Citation
Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Rauh, U; Bömer, U; Hillig, R; Lechner, C; Mortier, JX; Kaulfuss, S; Corsello, S; Handing, K; Madec, A; Furst, L; Shekhar, M; McKinney, D ARYL SUBSTITUTED PYRROLO-PYRIDINONES AND THERAPEUTIC USES THEREOF US Patent US20230322767 Publication Date 10/12/2023
More Info.:
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
Inhibitor
Name:
BDBM625312
Synonyms:
4-[2-({4-[3-(4-fluorophenyl)-5-methyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}amino)-2-oxoethyl]-N-(2-methoxyethyl)benzamide | US20230322767, Example 140
Type:
Small organic molecule
Emp. Form.:
C31H30FN5O4
Mol. Mass.:
555.5994
SMILES:
COCCNC(=O)c1ccc(CC(=O)Nc2cc(ccn2)-c2[nH]c3CCN(C)C(=O)c3c2-c2ccc(F)cc2)cc1