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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM627271
Substrate
n/a
Meas. Tech.
DGAT2 Enzymatic Activity Assay
IC50
0.900±n/a nM
Citation
 Lim, Y; Hugelshofer, CL; Mak, VW; Roane, JP; Sanzone, JR; Shockley, SE; Yen, R Diacylglyceride O-acyltransferase 2 inhibitors US Patent  US11787810 Publication Date 10/17/2023 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM627271
Synonyms:
3-[3-(cyclopropoxy)phenyl]- 1-isopropyl-N-(3-methyl-1,1- dioxo-thietan-3- yl)pyrazolo[4,3-b]pyridine-6- carboxamide | US11787810, Example 97 | US20240059700, Example 97
Type:
Small organic molecule
Emp. Form.:
C23H26N4O4S
Mol. Mass.:
454.542
SMILES:
CC(C)n1nc(-c2cccc(OC3CC3)c2)c2ncc(cc12)C(=O)NC1(C)CS(=O)(=O)C1
Structure:
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