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Target
Casein kinase I isoform alpha
Ligand
BDBM636432
Substrate
n/a
Meas. Tech.
CSNK1A1 Assay 2
IC50
1.50±n/a nM
Citation
 Schulze, V; Mengel, A; Faria Alvares De Lemos, AC; Rauh, U; Bömer, U; Hillig, R; Lechner, C; Mortier, JX; Sülzle, D; Kaulfuss, S; Corsello, S; Handing, K; Caliman, A; Madec, A SUBSTITUTED PYRROLO-PYRIDINONE DERIVATIVES AND THERAPEUTIC USES THEREOF US Patent  US20230365554 Publication Date 11/16/2023 
Target
Name:
Casein kinase I isoform alpha
Synonyms:
CK1 | CKI-alpha | CSNK1A1 | Casein Kinase I | Casein kinase 1 alpha (CK1 alpha) | Casein kinase I isoform alpha/delta | KC1A_HUMAN
Type:
Serine/threonine-protein kinase
Mol. Mass.:
38936.59
Organism:
Homo sapiens (Human)
Description:
P48729
Residue:
337
Sequence:
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF
  
Inhibitor
Name:
BDBM636432
Synonyms:
N-{4-[3-anilino-7-ethyl-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}-2-(4-fluorophenyl)acetamide (Racemate) | US20230365554, Example 1 | US20230365554, Example 2 | US20230365554, Example 3
Type:
Small organic molecule
Emp. Form.:
C28H26FN5O2
Mol. Mass.:
483.5367
SMILES:
CCC1CNC(=O)c2c(Nc3ccccc3)c([nH]c12)-c1ccnc(NC(=O)Cc2ccc(F)cc2)c1
Structure:
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