Reaction Details Report a problem with these data
Target
Dual specificity protein kinase CLK2
Ligand
BDBM644508
Substrate
n/a
Meas. Tech.
Biochemical Assay for Inhibitors of CLK2 Kinase Activity Assay
IC50
232±n/a nM
Citation
Hyvonen, MJ; Brear, P; Spring, DR; Glossop, P Benzo[c][2,6]naphthyridine derivatives, compositions and therapeutic uses thereof US Patent US11866436 Publication Date 1/9/2024
More Info.:
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN
Type:
n/a
Mol. Mass.:
60128.79
Organism:
Homo sapiens (Human)
Description:
P49760
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
Inhibitor
Name:
BDBM644508
Synonyms:
5-(3-(4-((3- (cyanomethyl)- 5-(trifluoro- methyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid | US11866436, Example 103
Type:
Small organic molecule
Emp. Form.:
C30H28F3N5O3
Mol. Mass.:
563.5702
SMILES:
OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(CC#N)cc(c1)C(F)(F)F)c1ccncc21